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. 2023 Jun 20;14:3650. doi: 10.1038/s41467-023-39196-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Samples in Arm C were subgrouped, according to the density of CD137+ CD8+ T cells in TLAs by using the mean of the density as cutoff, into two cohorts: low (n = 4) vs. high (n = 4) CD137+ T cells. The density of CD45+ CD3+ CD8+ TIGIT+ T cells was compared between the two cohorts. b The percentage of CD45+ CD3+ CD8+ CD137+ T cells among CD45+ CD3+ CD8+ T cells was compared between treatment arms. GVAX (Arm A) vs GVAX+PD-1+CD137 (Arm C): p = 0.0012, GVAX+PD-1 (Arm B) vs. GVAX+PD-1+CD137 (Arm C): p = 0.0002. Arm A: n = 7; Arm B: n = 8; Arm C: n = 8. c The percentage of CD45+ CD3+ CD8+ GZMB+ T cells among CD45+ CD3+ CD8+ T cells was compared between treatment arms. Arm A: n = 10; Arm B: n = 10; Arm C: n = 8. d The density of CD45+ CD3+ CD8+ CD137+ T cells in the tumor vicinity area outside TLAs, calculated as the percentage among all cells, was compared between treatment arms, GVAX (Arm A) vs GVAX+PD-1+CD137 (Arm C): p = 0.0003, GVAX+PD-1 (Arm B) vs. GVAX+PD-1+CD137 (Arm C): p = 0.0002. Arm A: n = 7; Arm B: n = 8; Arm C: n = 8. All data shown as the mean ± SD. Treatment arms as indicated. Two-sided Mann–Whitney tests were performed; p values were shown: *<0.05; **<0.01; ***<0.001; if not shown, non-significance. Multiplex IHC analysis was repeated twice with consistent results.