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. 2023 Jun 21;14:3673. doi: 10.1038/s41467-023-39401-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Protein levels of SLC7A11, SLC7A9, and SLC3A1 in a panel of cancer cell lines. Vinculin was used as the loading control. b Cystine uptake levels in a panel of cancer cell lines. c Protein levels of SLC7A11 (up) and cystine uptake levels (down) in sgCtrl and SLC7A11 knockout T98G cells. d Cell death in response to 1 mM H₂O₂ treatment (up) or glucose starvation (down) in T98G cells with indicated genotypes for 24 h was measured using PI staining. e Protein levels of SLC7A11 (up) and cystine uptake levels (down) in shCtrl and SLC7A11 knockdown T98G cells. f Cell death in response to 1 mM H₂O₂ treatment (up) or glucose starvation (down) in T98G cells with indicated genotypes for 24 h was measured using PI staining. g Protein levels of SLC7A11 (up) and cystine uptake levels (down) in sgCtrl and SLC7A11 knockout Hs578T cells. h Cell death in response to 1 mM H₂O₂ treatment (up) or glucose starvation (down) in Hs578T cells with indicated genotypes for 24 h was measured using PI staining. i Protein levels of SLC7A11 (up) and cystine uptake levels (down) in shCtrl and SLC7A11 knockdown Hs578T cells. j Cell death in response to 1 mM H₂O₂ treatment (up) or glucose starvation (down) in Hs578T cells with indicated genotypes for 24 h was measured using PI staining. k Protein levels of SLC7A11 (up) and cystine uptake levels (down) in SLC7A11-low, -moderate, and -high H1299 cells. l Cell death in response to 1 mM H₂O₂ treatment (left) or glucose starvation (right) for 20 h in SLC7A11-low, -moderate, and -high H1299 cells was measured using PI staining. m Protein levels of SLC7A11 (up) and corresponding cystine uptake levels (down) in SLC7A11-low, -moderate, and -high 786-O cells. n Cell death in response to 1 mM H₂O₂ treatment (left) or glucose starvation (right) in SLC7A11-low, -moderate, and -high 786-O cells for 20 h measured using PI staining. Data were presented as mean ± SD; n = 3. n indicates independent repeats. P value was determined by two-tailed unpaired Student’s t test. Source data are provided as a Source Data file.