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. 2023 Jun 20;14:3659. doi: 10.1038/s41467-023-39436-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a qRT PCR on vit transcripts after treatment with FAC or DFO, normalised to actin. Points represent 4 independent experiments, bars at mean ± SD. p values from two tailed one sample t-test. b Western blot showing levels of VIT-HA after 24 h treatment with 100 μM DFO or 5 mM FAC. TOM40 used as a loading control. c Quantification of VIT-HA levels from three independent experiments, bar at mean ± SD, p values from one sample two tailed t test. d VIT-HA foci at 6 h post invasion after treatment with FAC or DFO. There was no significant change upon FAC treatment, however, there was a significant decrease in the number of foci upon DFO treatment. POL polarised light. Results from 3 independent experiments, n = 300 parasites. p values from one way ANOVA with Tukey correction. e As above, but quantified at 24 h post invasion. There was a significant decrease in the number of foci after treatment with both FAC and DFO, p values from one way ANOVA with Tukey correction. Results from 3 independent experiments, n = 300 parasites. p values from one way ANOVA with Tukey correction. f Volcano plot from RNAseq data comparing the parental line to ΔVIT. Adjusted p values from Wald test with Benjamini and Hochberg correction. See text for more details.