Table 3.
% Change in biochemical markers of bone turnover; β C-terminal telopeptide (βCTX) and total procollagen 1 N-terminal propeptide (P1NP) over time (months) following intention to treat (ITT) analysis
| CTX | |||||||
|
Time points Months |
Placebo n = 30 |
95% CI |
Vitamin K1 arm n = 32 |
95% CI |
MK-4 n = 31 |
95% CI | P value |
| 3 | 5 | -13, 24 | 2 | -10, 13 | 8 | -6.4, 22 |
0.6* 0.6# |
| 6 | 7 | -10.0, 24 | -6 | -18, 5.7 | 5 | -9.1, 20 |
0.43* 0.95# |
| 12 | 15 | -1.9, 32 | 5 | -8.3, 18 | 22 | 4.3, 40 |
0.6* 0.55# |
| 18 | 18 | -4.5, 41 | 16 | -5.1, 37 | 20 | 4.4, 36 |
0.84* 0.54# |
| P1NP | |||||||
|
Time points Months |
Placebo n = 30 |
95% CI |
Vitamin K1 arm n = 32 |
95% CI |
MK4 n = 31 |
95% CI | P value |
| 3 | 0 | -6.7, 6.9 | 2 | -7.0, 10 | 7 | -4.7, 19 |
0.3* 0,4# |
| 6 | 11 | -0.93, 23 | -4 | -14, 6.9 | 8 | -4.8, 22 |
0.3* 0.7# |
| 12 | 29 | 1.1, 57 | 5 | -9.4, 20 | 13 | 0.65, 26 |
0.13* 0.38# |
| 18 | 22 | 11, 32 | 7 | -6.4, 21 | 40 | -1.2, 81 |
0.42* 0.8# |
No significant differences were seen between vitamin K1 arm, MK-4 arm and placebo. Results are expressed as mean and 95% confidence interval (CI) p* vitamin K1 v/s placebo, p# MK-4 v/s placebo