TABLE 4.
Risk factors for hypofibrinogenemia by logistic regression.
| Risk factors | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Or (95% CI) | p | Or (95% CI) | p | |
| Gender (Female VS. Male) | 1.59 (1.03–2.47) | 0.036 a | 1.34 (0.66–2.71) | 0.417 |
| Age, years | ||||
| ≥50 VS. <50 | 0.90 (0.47–1.72) | 0.748 | 1.13 (0.44–2.89) | 0.794 |
| ≥60 VS. <50 | 1.54 (0.87–2.74) | 0.141 | 1.99 (0.83–4.75) | 0.124 |
| ≥70 VS. <50 | 1.98 (1.07–3.69) | 0.031 a | 2.03 (0.76–5.39) | 0.156 |
| ≥80 VS. <50 | 2.74 (1.39–5.37) | 0.003 a | 2.85 (1.07–7.60) | 0.036 a |
| Treatment duration | 1.14 (1.08–1.19) | <0.001 a | 1.29 (1.19–1.41) | <0.001 a |
| Daily dose (200 mg VS. 100 mg) | 1.55 (0.94–2.55) | 0.085 | 2.60 (1.29–5.25) | 0.008 a |
| Total bilirubin | 1.01 (1.01–1.02) | 0.020 a | 1.01 (1.01–1.02) | 0.003 a |
| ALT | 0.99 (0.99–1.01) | 0.124 | ||
| AST | 1.00 (0.99–1.01) | 0.702 | ||
| Serum creatinine | 1.00 (1.00–1.01) | 0.139 | ||
| White blood cell | 1.02 (0.99–1.05) | 0.191 | ||
| Erythrocyte | 0.99 (0.98–0.99) | 0.022 a | 0.99 (0.97–1.00) | 0.082 |
| Platelet | 0.99 (0.98–0.99) | 0.008 a | 0.99 (0.99–1.00) | 0.052 |
| Basal fibrinogen | 1.45 (1.18–1.86) | 0.005 a | 1.32 (1.14–1.63) | 0.023 a |
a
p < 0.05.
ALT, alanine aminotransferase; AST, aspartate aminotransferase.