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Assessment of the effect of host cell derivation and monoclonal antibody binding to DEN VLPs, as determined by ELISA assay. (A) Binding of HuMAb C10 to DEN-2 VLPs produced in Huh7 cells, Vero cells and Vero-Furin cells (negative control PBS). (B) Titration of C10 binding to DEN-2 VLPs. (C) Binding of C10 and A11 to DEN-2 VLPs. One-way ANOVA was used to determine significance in (A) (p < 0.05, * < 0.05, ** < 0.005, *** < 0.0005, **** < 0.0001).
