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. 2023 Jun 7;14:1065609. doi: 10.3389/fmicb.2023.1065609

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Copyright © 2023 Collett, Earnest, Carrera Montoya, Edeling, Yap, Wong, Christiansen, Roberts, Mumford, Lecouturier, Pavot, Marco, Loi, Simmons, Gulab, Mackenzie, Elbourne, Ramsland, Cameron, Hans, Godfrey and Torresi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NKT cell activation induced by self-adjuvanted DEN VLPs. Splenocytes (C57BL/6) were stimulated for 4 days in vitro under the indicated condition prior to FACS analysis. Numbers on plots indicate the percentage of NKT cells amongst viable (7-AAD-), CD19- lymphocytes. (A) Dose response of DEN-4 VLPs generated with differing concentrations of α-GalCer. (B) Data pooled from two independent experiments at 10 µg/mL VLP dose. (C) Comparison of NKT cell expansion using VLPs from the indicated serotype, shown in comparison to α-GalCer alone and vehicle controls from 1 experiments (see Supplementary Figure 3).