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. 2023 Jun 7;14:1132661. doi: 10.3389/fimmu.2023.1132661

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Copyright © 2023 Wu, Wang, Liu, Zhang, Wang and Miao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Landscape of expression level and survival outcomes of across human pan-cancer. (A) The cuproptosis score based on the gene expression from the TCGA database calculated by ssGSEA algorithm. (B) Cuproptosis score was significantly downregulated in multiple cancers. (C) The expression patterns of these cuproptosis regulators among TCGA pan-cancer dataset. (D) Somatic copy number alterations (SCNA) frequency of these cuproptosis regulators. (E) The association between cuproptosis resistances and overall survival outcomes. (F) Functional enrichment analysis of these cuproptosis regulators genes. *: p<0.05; ***: p<0.001; ****: p<0.0001.