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. 2023 Jun 7;14:1132661. doi: 10.3389/fimmu.2023.1132661

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Copyright © 2023 Wu, Wang, Liu, Zhang, Wang and Miao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell and bulk RNA-seq revealed the distinct landscape of cuproptosis regulator genes in ccRCC. (A) The cell viability of 786-O, Caki-1, A498 and 769-P cells decreased significantly after cuproptosis activator (elesclomol) treatment. (B) The expression pattern of these cuproptosis-related genes in ccRCC and adjacent normal tissues. (C) Correlation analysis of these cuproptosis-related genes. (D) The protein expression level of these cuproptosis regulators in CPTAC-ccRCC database. (E) Single-cell RNA-seq illustrated the distribution of copper-induced cell death scores by “AddModuleScore” algorithm. (F) Copper-induced cell death signature was significantly down-regulated in ccRCC tumors tissues compared with normal samples both in all cells and tumor cells. (G) The cell proportion among different patients and correlations of PDHB expression level.