Table 2.
Performance of the QCOVID1, QCOVID2, and QCOVID4 algorithms in men and women in validation cohort
| Statistic | Covid-19 related deaths | Hospital admission for covid-19 | |||
|---|---|---|---|---|---|
| Women | Men | Women | Men | ||
| QCOVID1 | |||||
| R2 (%) | 73.6 (71.0 to 76.1) | 73.0 (70.6 to 75.4) | 27.6 (24.7 to 30.5) | 48.4 (45.6 to 51.2) | |
| D statistic | 3.41 (3.19 to 3.64) | 3.36 (3.16 to 3.57) | 1.26 (1.17 to 1.36) | 1.98 (1.87 to 2.09) | |
| Harrell’s C | 0.945 (0.928 to 0.963) | 0.948 (0.933 to 0.963) | 0.684 (0.669 to 0.7) | 0.798 (0.781 to 0.814) | |
| Calibration slope* | NA | NA | NA | NA | |
| QCOVID2 | |||||
| R2 (%) | 75.4 (73.1 to 77.7) | 74.1 (71.8 to 76.4) | 67.4 (64.1 to 70.7) | 68.2 (65.2 to 71.2) | |
| D statistic | 3.58 (3.36 to 3.81) | 3.46 (3.25 to 3.67) | 2.94 (2.72 to 3.16) | 3.00 (2.79 to 3.21) | |
| Harrell’s C | 0.968 (0.959 to 0.978) | 0.959 (0.946 to 0.971) | 0.939 (0.930 to 0.948) | 0.932 (0.918 to 0.945) | |
| Calibration slope | NA | NA | NA | NA | |
| QCOVID4 | |||||
| R2 (%) | 76.6 (74.4 to 78.8) | 76.0 (73.9 to 78.2) | 73.9 (71.5 to 76.3) | 74.4 (72.1 to 76.6) | |
| D statistic | 3.70 (3.48 to 3.93) | 3.65 (3.43 to 3.86) | 3.44 (3.23 to 3.66) | 3.49 (3.28 to 3.69) | |
| Harrell’s C | 0.965 (0.951 to 0.978) | 0.970 (0.962 to 0.979) | 0.965 (0.956 to 0.973) | 0.970 (0.963 to 0.977) | |
| Calibration slope | 1.01 (0.93 to 1.09) | 1.00 (0.936 to 1.07) | 0.996 (0.956 to 1.04) | 1.01 (0.972 to 1.06) | |
Values are mean (95% confidence interval). NA=not applicable.
*
Calibration not assessed because QCOVID1 and QCOVID2 were based on the whole population rather than restricted to the subset with a positive test result for SARS-CoV-2 infection.