Table 1.
Summary of the enrichment with GSEA of each identified module.
| EMT | ECM | Glycolysis | Angiogenesis | RAS | PI3K | Hypoxia | ||
|---|---|---|---|---|---|---|---|---|
| GiGA | Module 1 | 7.78 × 10−31 | 2.23 × 10−6 | 8.76 × 10−6 | 2.16 × 10−11 | 1.52 × 10−12 | 2.19 × 10−2 | |
| Module 2 | 1.99 × 10−8 | 3.4 × 10−9 | 5.67 × 10−8 | |||||
| Module 3 | ||||||||
| Module 4 | 1.7 × 10−2 | 1.27 × 10−3 | ||||||
| Module 5 | 2.9 × 10−2 | |||||||
| BioNet | Module 1 | |||||||
| Module 2 | ||||||||
| Module 3 | 1.8 × 10−2 | |||||||
| Module 4 | 6.33 × 10−14 | 1.5 × 10−9 | 5.4 × 10−11 | |||||
| Module 5 | ||||||||
| DIAMOnD | Module 1 | 8.63 × 10−25 | 9.38 × 10−43 | 1.07 × 10−3 | 6.97 × 10−26 | |||
| DOMINO | Module 1 | 3.10 × 10−30 | 6.43 × 10−27 | 6.18 × 10−6 | 6.96 × 10−8 | 2.59 × 10−16 | ||
| Module 2 | 5.28 × 10−10 | 6.44 × 10−9 | ||||||
| Module 3 | 9.88 × 10−6 | 7 × 10−3 | 5 × 10−3 | 5.29 × 10−4 | ||||
| Module 4 | ||||||||
| Module 5 | ||||||||
| AMINE | Module 1 | 1.65 × 10−16 | 4.9 × 10−11 | 2.75 × 10−6 | 1.43 × 10−8 | 1.41 × 10−5 | 2.2 × 10−4 | |
| Module 2 | 3.32 × 10−5 | 6.20 × 10−10 | ||||||
| Module 3 | 4.57 × 10−7 | 3.9 × 10−3 | 1.29 × 10−5 | |||||
| Module 4 | 4.57 × 10−5 | 3.39 × 10−9 | ||||||
| Module 5 | 1.53 × 10−2 | 3.42 × 10−14 | 1.06 × 10−3 |
First two columns list the name of the methods and the identified modules. The following columns contain the false discovery rate associated with hallmarks related to metastatic PDAC cells, that is, epithelial–mesenchymal transition, ECM organization, glycolysis (carbohydrate metabolism) angiogenesis, RAS and PI3K/AKT pathways, and finally, hypoxia.