Table 3.
Association of WHtR with biomarkers of metabolic dysfunction, inflammation, endothelial dysfunction and CVD risk in the studied population: Caucasian prepubertal children aged 6–12 years from three cities in Spain (Cordoba, Santiago de Compostela and Zaragoza), May 2007–May 2010
| Biomarker | r | P value |
|---|---|---|
| Metabolic | ||
| Systolic BP | 0·408 | <0·001 |
| Diastolic BP | 0·353 | <0·001 |
| Insulin | 0·508 | <0·001 |
| HOMA-IR | 0·487 | <0·001 |
| TAG | 0·317 | <0·001 |
| HDL-C | −0·424 | <0·001 |
| Adiponectin | −0·211 | <0·001 |
| Resistin | 0·272 | <0·001 |
| Inflammation | ||
| Leucocytes | 0·162 | 0·002 |
| CRP | 0·325 | <0·001 |
| IL-6 | 0·110 | 0·030 |
| IL-8 | 0·130 | 0·008 |
| TNF-α | 0·215 | <0·001 |
| Endothelial dysfunction and CVD risk | ||
| sICAM-1 | 0·127 | 0·009 |
| sE-selectin | 0·250 | <0·001 |
| MPO | 0·109 | 0·030 |
| Active PAI-1 | 0·464 | <0·001 |
| Total PAI-1 | 0·295 | <0·001 |
WHtR, waist-to-height ratio; BP, blood pressure; HOMA-IR, homeostasis model assessment of insulin resistance; HDL-C, HDL-cholesterol; CRP, C-reactive protein; sICAM-1, soluble intercellular adhesion molecule-1; sE-selectin, soluble endothelial selectin; MPO, myeloperoxidase; PAI-1, plasminogen activator inhibitor-1.