Table 5. Patient characteristics and outcomes.
Patient | PVTT (15) | HVT (15) | Baseline AFP (ng/mL) | Index tumor size (mm) | Best mRECIST response† | PN | MVE | Post-treatment tumor-absorbed dose (Gy) | TTS (months) | TTR (months) |
---|---|---|---|---|---|---|---|---|---|---|
1 | VP2 | – | 15.6 | 89 | CR | Extensive | 1 | 225 | 13.6 | 49.3 |
2 | VP4 | – | 44.2 | 111 | PR | Extensive | 0 | 169 | 8 | 21.5 |
3 | VP2 | – | 3,071 | 93 | CR | CPN | 0 | 304 | 5.8 | – |
4 | VP3 | – | 1,032 | 50 | PR | Extensive | 1 | 186 | 4.2 | – |
5 | VP2 | – | 3.4 | 32 | SD | Partial | 0 | 31 | 2.1 | – |
6 | VP3 | – | 7.5 | 47 | PR | Extensive | 0 | 322 | 4.1 | 10.3 |
7 | VP2 | – | 38.4 | 41 | CR | CPN | 0 | 394 | 7.8 | – |
8 | VP1 | VV2 | 72.2 | 42 | CR | CPN | 0 | 388 | 8.3 | – |
9 | VP2 | – | 15.4 | 37 | PR | Extensive | 1 | 396 | 3.7 | 14 |
10 | VP2 | VV1 | 2.2 | 77 | PR | Extensive | 1 | 318 | 7.2 | 22.5 |
11 | – | VV1 | 61 | 37 | PR | CPN | 0 | 515 | 6.2 | 7.4 |
29 | – | Partial | – | 148 | – | – | ||||
34 | – | Extensive | – | 382 | – | – | ||||
12 | VP3 | – | 3.5 | 20 | CR | CPN | 0 | 1,131 | 14.6 | – |
13 | – | – | 16.7 | 26 | PR | CPN | 1 | 497 | 10.5 | – |
56 | – | Partial | – | 340 | – | – | ||||
14 | – | – | 12.5 | 150 | PR | Partial | 1 | 225 | 3.5 | 10.1 |
15 | VP3 | – | 13.1 | 26 | CR | CPN | 0 | 293 | 9.7 | – |
37 | – | CPN | – | 506 | – | – | ||||
16 | – | – | 60 | 91 | CR | Extensive | 0 | 311 | 4.3 | – |
17 | VP3 | – | 13.7 | 55 | PR | Extensive | 0 | 678 | 6.2 | – |
18 | VP2 | – | 69.8 | 74 | PR | Extensive | 0 | 655 | 3.9 | – |
†, best mRECIST response = best localized mRECIST response = localized mRECIST response prior to surgery. PVTT, portal vein tumoral thrombosis; HVT, hepatic vein thrombosis; AFP, alpha fetoprotein; mRECIST, modified response evaluation criteria in solid tumors; CR, complete response; PR, partial response; SD, stable disease; PN, pathological necrosis; MVE, microvascular embolism; TTS, time to surgery; TTR, time to recurrence; CPN, complete pathological necrosis; VP1, tumor thrombus distal to the second-order branches of portal vein; VP2, invasion of the second-order branches of portal vein; VP3, thrombus in the first-order branches; VP4, tumor thrombus in main portal trunk or portal branch contralateral to primarily involved lobe (or both); VV1, tumor thrombus in a branch of the hepatic vein; VV2, tumor thrombus in the main trunk of the hepatic veins.