Skip to main content
. 2023 Jun 13;43(6):246–256. doi: 10.1089/jir.2022.0078

FIG. 2.

FIG. 2.

Suppressed cytokine secretion by fingolimod via PP2A activation. The PP2A activator fingolimod overcomes OA-mediated inhibition of basal PP2A phosphatase activity and significantly represses IL-6 and IL-8 mRNA expression and cytokine secretion. A549 cells were treated for 6 h with 2.5 μM fingolimod before 45 min with 1 μM OA, compared with vehicle. IL-6 and IL-8 protein secretion measured at 24 h. *Denotes a significant effect of OA and §for fingolimod (P < 0.05). Data are mean + SEM values from three independent experiments. Figure adapted from Rahman and others (2015). mRNA, messenger RNA; OA, okadaic acid; PP2A, protein phosphatase 2A; SEM, standard error of mean. Reproduced under Creative Commons Attribution 4.0 International License from Rahman MM, Rumzhum NN, Morris JC, Clark AR, Verrills NM, Ammit AJ. Scientific Report 2015 May 18;5:10063; DOI: 10.1038/srep10063.