Table 4.
Visual Acuity Score (in Letters) by Predominantly Persistent Intraretinal Fluid
| No |
Yes |
Between-Group Difference |
||||
|---|---|---|---|---|---|---|
| Visual Acuity, Letters | n * | Mean (SE) | n * | Mean (SE) | Mean (95% CI) | P |
| Predominantly persistent intraretinal fluid through wk 12 | ||||||
| At wk 12 | ||||||
| Unadjusted | 247 | 68.1 (1.0) | 116 | 60.8 (1.4) | −7.3 (−10.7 to −4.0) | < 0.001 |
| Adjusted | 238 | 66.6 (0.7) | 109 | 63.8 (1.0) | −2.8 (−5.2 to −0.4) | 0.02† |
| Change at wk 12 | ||||||
| Unadjusted | 247 | 6.4 (0.7) | 116 | 4.0 (1.0) | −2.3 (−4.7 to 0.0) | 0.052 |
| Adjusted | 241 | 6.3 (0.6) | 111 | 4.2 (1.0) | −2.1 (−4.4 to 0.2) | 0.07‡ |
| Predominantly persistent intraretinal fluid through yr 1 | ||||||
| At yr 1 | ||||||
| Unadjusted | 255 | 68.5 (1.1) | 108 | 62.4 (1.7) | −6.1 (−10.0 to −2.2) | 0.002 |
| Adjusted | 244 | 67.4 (0.9) | 103 | 65.0 (1.3) | −2.4 (−5.6 to 0.7) | 0.13† |
| Change at yr 1 | ||||||
| Unadjusted | 255 | 6.9 (0.9) | 108 | 5.8 (1.4) | −1.1 (−4.2 to 2.1) | 0.51 |
| Adjusted | 247 | 7.1 (0.8) | 105 | 5.1 (1.3) | −2.0 (−5.1 to 1.0) | 0.19‡ |
| Predominantly persistent intraretinal fluid through yr 2 | ||||||
| At yr 2 | ||||||
| Unadjusted | 219 | 68.9 (1.2) | 94 | 61.0 (1.8) | −7.9 (−12.1 to −3.6) | < 0.001 |
| Adjusted | 209 | 68.3 (1.0) | 88 | 63.0 (1.5) | −5.3 (−8.9 to −1.7) | 0.004† |
| Change at yr 2 | ||||||
| Unadjusted | 219 | 6.5 (1.1) | 94 | 3.6 (1.6) | −2.9 (−6.7 to 0.9) | 0.13 |
| Adjusted | 211 | 7.1 (1.0) | 91 | 2.4 (1.5) | −4.8 (−8.4 to −1.2) | 0.009‡ |
CI = confidence interval; SE = standard error.
In the adjusted analyses, a small number of eyes were excluded because of missing data for ≥ 1 baseline covariates used in the adjustment.
Visual acuity score was adjusted for baseline predictors of visual acuity, including age, study eye visual acuity, macular neovascularization area, lesion type, study eye macular atrophy, total foveal thickness, retinal pigment epithelium elevation, and predominantly persistent subretinal fluid over the same duration.
Visual acuity change from baseline was adjusted for baseline predictors, including age, study eye visual acuity, macular neovascularization area, retinal angiomatous proliferation, and retinal pigment epithelium elevation, and predominantly persistent subretinal fluid over the same duration.