. Author manuscript; available in PMC: 2023 Jun 21.

Published in final edited form as: Ophthalmol Retina. 2022 Apr 9;6(9):771–785. doi: 10.1016/j.oret.2022.03.024

Table 5.

Year 2 Macular Atrophy and Scar Risk by Predominantly Persistent Intraretinal Fluid through Year 2

	Predominantly Persistent Intraretinal Fluid through Yr 2		Unadjusted		Adjusted
Outcome at Year 2	No	Yes	Hazard Ratio (95% CI)	P	Hazard Ratio (95% CI)	P
Macular atrophy (%)	31 (15.5%)	16 (18.8%)	1.21 (0.66–2.21)	0.54	1.32 (0.66–2.63)	0.44^*
Scar (%)	93 (43.5%)	56 (64.4%)	1.68 (1.20–2.34)	0.002	1.49 (1.03–2.14)	0.03^†

CI = confidence interval.

Hazard ratio for 2-year risk of macular atrophy adjusted by the baseline features: study eye visual acuity, retinal angiomatous proliferation, blocked fluorescence, fellow eye macular atrophy, subretinal fluid thickness at the foveal center, subretinal tissue complex at the foveal center, vitreomacular attachment, drug group, and regimen group.

^†

Hazard ratio for 2-year risk of scar adjusted by the baseline features: baseline fellow eye visual acuity, macular neovascularization lesion type, lesion-associated hemorrhage, retinal thickness at the foveal center, subretinal fluid thickness at the foveal center, subretinal tissue complex thickness at the foveal center, retinal pigment epithelial elevation, and subretinal hyperreflective material.