Table 7.

Cross-Sectional Association between Visual Acuity Score (in Letters) and the Presence of Intraretinal Fluid at the Time of Visual Acuity Measurement among Patients with Baseline Intraretinal Fluid and Eligible for Year 1 Predominantly Persistent Intraretinal Fluid Analysis

	Intraretinal fluid at the time of visual acuity measurement
	No		Yes		Between-Group Difference
Visual Acuity, Letters	n	Mean (SE)	n	Mean (SE)	Mean (95% CI)	P
At wk 12
Unadjusted	155	68.4 (1.2)	207	63.8 (1.1)	−4.6 (−7.8 to −1.4)	0.005
Adjusted*	150	67.4 (0.8)	196	64.4 (0.7)	−3.0 (−5.3 to −0.8)	0.008
At yr 1
Unadjusted	151	69.7 (1.4)	207	64.8 (1.2)	−4.8 (−8.5 to −1.2)	0.01
Adjusted*	142	68.2 (1.1)	200	65.9 (0.9)	−2.3 (−5.1 to 0.6)	0.12
At yr 2 (within yr 1 cohort)
Unadjusted	131	71.4 (1.5)	198	62.7 (1.3)	−8.7 (−12.6 to −4.8)	< 0.001
Adjusted*	126	69.7 (1.3)	187	64.0 (1.1)	−5.6 (−9.0 to −2.3)	0.001

CI = confidence interval; SE = standard error.

^*Adjusted for baseline predictors of visual acuity, including age, study eye visual acuity, macular neovascularization area, lesion type, study eye macular atrophy, total foveal thickness, retinal pigment epithelium elevation, and predominantly persistent subretinal fluid. The baseline predictors of visual acuity change include age, study eye visual acuity, macular neovascularization area, retinal angiomatous proliferation, and retinal pigment epithelium elevation.