Table 8.
Visual Acuity Score (in Letters) by Baseline Intraretinal Fluid among Patients with at Least 75% OCT Visits within Year 1
| Baseline intraretinal fluid |
||||||
|---|---|---|---|---|---|---|
|
No
|
Yes
|
Between-Group Difference
|
||||
| Visual Acuity, Letters | n * | Mean (SE) | n * | Mean (SE) | Mean (95% CI) | P |
| At wk 12 | ||||||
| Unadjusted | 116 | 72.8 (1.4) | 363 | 65.8 (0.8) | −7.0 (−10.1 to −4.0) | < 0.001 |
| Adjusted | 115 | 68.7 (1.0) | 347 | 67.1 (0.6) | −1.7 (−4.0 to 0.6) | 0.15† |
| Change at wk 12 | ||||||
| Unadjusted | 116 | 6.1 (0.9) | 363 | 5.6 (0.5) | −0.5 (−2.7 to 1.6) | 0.64 |
| Adjusted | 115 | 6.9 (0.9) | 347 | 5.4 (0.5) | −1.5 (−3.6 to 0.6) | 0.16‡ |
| At yr 1 | ||||||
| Unadjusted | 116 | 73.8 (1.6) | 363 | 66.7 (0.9) | −7.1 (−10.6 to −3.6) | < 0.001 |
| Adjusted | 115 | 69.6 (1.3) | 347 | 68.1 (0.7) | −1.5 (−4.4 to 1.5) | 0.33† |
| Change at year 1 | ||||||
| Unadjusted | 116 | 7.2 (1.3) | 363 | 6.6 (0.7) | −0.6 (−3.4, 2.2) | 0.68 |
| Adjusted | 115 | 7.9 (1.2) | 347 | 6.3 (0.7) | −1.6 (−4.4 to 1.1) | 0.25‡ |
| At yr 2 | ||||||
| Unadjusted | 108 | 73.8 (1.7) | 344 | 65.9 (0.9) | −7.9 (−11.6 to −4.2) | < 0.001 |
| Adjusted | 107 | 70.2 (1.5) | 328 | 66.9 (0.8) | −3.2 (−6.7 to 0.2) | 0.06† |
| Change at yr 2 | ||||||
| Unadjusted | 108 | 6.8 (1.5) | 344 | 5.5 (0.9) | −1.3 (−4.7 to 2.1) | 0.46 |
| Adjusted | 107 | 8.2 (1.4) | 328 | 5.2 (0.8) | −3.1 (−6.3 to 0.2) | 0.07‡ |
CI = confidence interval; SE = standard error.
In the adjusted analyses, a small number of eyes were excluded because of missing data for ≥ 1 baseline covariates used in the adjustment.
Visual acuity score was adjusted for baseline predictors of visual acuity, including age, study eye visual acuity, macular neovascularization area, lesion type, study eye macular atrophy, total foveal thickness, retinal pigment epithelium elevation, and predominantly persistent subretinal fluid.
The baseline predictors of visual acuity change include age, study eye visual acuity, macular neovascularization area, retinal angiomatous proliferation, retinal pigment epithelium elevation, and predominantly persistent subretinal fluid over the same duration.