Table 10.
Association between KLF14 rs4731702 polymorphism and tested biochemical, clinical, and anthropometric parameters.
| Parameters | Control | Diabetic | Cardiodiabetic | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | P value | CC | CT | TT | P value | CC | CT | TT | P value | |
| HDL-C (mg/dl) | 59.86 ± 2.4 | 67.31 ± 3.0 | 72.87 ± 3.2 | <0.05 | 40.69 ± 4.5 | 44 ± 4.46 | 49.20 ± 5.4 | <0.05 | 25.59 ± 4.4 | 33.90 ± 3.87 | 39.64 ± 3.2 | <0.05 |
| LDL-C (mg/dl) | 126.5 ± 2.36 | 116.0 ± 2.45 | 105.6 ± 2.67 | <0.05 | 154.2 ± 2.2 | 144.2 ± 2.61 | 137.5 ± 4.69 | <0.05 | 186.1 ± 8.05 | 175.2 ± 3.64 | 163.8 ± 1.67 | <0.05 |
| ApoA1 (mg/dl) | 123.5 ± 6.22 | 139.4 ± 9.56 | 155.3 ± 5.21 | <0.05 | 69.37 ± 7.5 | 79.73 ± 9.64 | 136.1 ± 14.76 | <0.05 | 59.02 ± 4.42 | 68.83 ± 3.92 | 76.14 ± 5.31 | <0.05 |
| TGs (mg/dl) | 134.4 ± 6.5 | 135.0 ± 8.9 | 135.7 ± 8.0 | >0.05 | 235.3 ± 2.5 | 225.0 ± 2.5 | 215.5 ± 2.4 | <0.05 | 380.1 ± 43.5 | 301.1 ± 33 | 246.2 ± 21.9 | <0.05 |
| TC (mg/dl) | 178.6 ± 5.9 | 163.7 ± 4.4 | 145.0 ± 9.4 | <0.05 | 235.3 ± 2.5 | 225.0 ± 2.5 | 215.5 ± 2.3 | <0.05 | 264.6 ± 4.0 | 253.6 ± 3.01 | 244.0 ± 3.2 | <0.05 |
| Hb1Ac (%) | 4.829 ± 0.3 | 4.876 ± 0.3 | 4.917 ± 0.3 | >0.05 | 6.183 ± 0.3 | 6.158 ± 0.4 | 6.185 ± 0.3 | >0.05 | 8.926 ± 0.6 | 8.815 ± 0.54 | 8.779 ± 0.5 | >0.05 |
| HOMA-IR | 0.53 ± 0.1 | 0.55 ± 0.12 | 0.531 ± 0.1 | >0.05 | 1.823 ± 0.3 | 2.069 ± 0.3 | 1.615 ± 0.2 | <0.05 | 1.728 ± 0.2 | 2.050 ± 0.34 | 1.750 ± 0.3 | <0.05 |
| Fasting blood glucose (mg/dl) | 114.5 ± 5.4 | 115.6 ± 5.0 | 116.4 ± 5.6 | >0.05 | 164.0 ± 5.3 | 169.9 ± 3.1 | 154.5 ± 5.2 | <0.05 | 166.5 ± 5.1 | 170.4 ± 2.22 | 157.3 ± 4.3 | <0.05 |
| Hemoglobin (g/dl) | 13.95 ± 1 | 13.52 ± 1.1 | 13.66 ± 1.3 | <0.05 | 10.22 ± 1 | 10.36 ± 1.2 | 10.52 ± 1.2 | <0.05 | 10.25 ± 1.3 | 10.57 ± 1.5 | 10.3 ± 1.3 | <0.05 |
| Total protein (mg/dl) | 7.59 ± 0.4 | 7.616 ± 0.4 | 7.339 ± 0.6 | >0.05 | 7.951 ± 1.1 | 8.071 ± 0.2 | 8.100 ± 0.2 | >0.05 | 8.350 ± 0.3 | 8.38 ± 0.29 | 8.28 ± 0.4 | >0.05 |
| Systolic BP | 121.4 ± 6.3 | 121.7 ± 4.8 | 122.3 ± 5.7 | >0.05 | 120.8 ± 4.26 | 121.7 ± 9.8 | 119.2 ± 5.37 | >0.05 | 146.5 ± 15.14 | 149.3 ± 15.7 | 150.2 ± 16.93 | >0.05 |
| Diastolic BP | 76.39 ± 3.31 | 76.55 ± 2.96 | 78.22 ± 2.08 | >0.05 | 77.03 ± 2.8 | 77.69 ± 2.72.26 | 78.20± | >0.05 | 84.33 ± 5.4 | 86.80 ± 5.8 | 85.36 ± 4.12 | >0.05 |
| Female | 16% | 38% | 16% | – | 27% | 32% | 8% | – | 21% | 22% | 8% | – |
| Male | 12% | 11% | 7% | – | 8% | 13% | 12% | – | 25% | 18% | 6% | – |
| Age (<40) | 15 | 32 | 18 | – | 21 | 22 | 14 | – | 22 | 19 | 2 | – |
| Age (>40) | 13 | 17 | 5 | – | 14 | 23 | 6 | – | 24 | 21 | 12 | – |
| Smokers | 3 | 7 | 2 | – | 9 | 13 | 11 | – | 12 | 10 | 3 | – |
| Non-smokers | 25 | 42 | 21 | – | 26 | 32 | 9 | – | 34 | 30 | 11 | – |
| Obese | 0 | 0 | 0 | – | 4 | 10 | 1 | – | 10 | 22 | 3 | – |
| Non-obese | 28 | 49 | 23 | – | 31 | 35 | 19 | – | 36 | 18 | 11 | – |