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. Author manuscript; available in PMC: 2023 Jun 21.
Published in final edited form as: Metabolism. 2022 Jan 22;129:155141. doi: 10.1016/j.metabol.2022.155141

Fig. 2.

Fig. 2.

Impact of central blockade of GRK2 on the timing of puberty onset in female rats. Immature female rats were injected icv with the GRK2 inhibitor, βARK1-I (red symbols), every 12 h, from PND25 to PND34; females injected icv with vehicle (VEH; grey symbols) served as controls (N = 11 rats/group). The parameters presented are: cumulative percentage of vaginal opening (VO; panel A) and first estrus (B), LH (C) and FSH (D) levels, as well as uterus (E) and ovary (F) weights. In addition, the histological score of follicular development/ovulation (Pub-score; panel G) and representative images of ovarian maturation (H) are presented from both groups. Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the vehicle-treated group (Student t-test). CL: corpus luteum.