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. Author manuscript; available in PMC: 2023 Jun 21.
Published in final edited form as: Metabolism. 2022 Jan 22;129:155141. doi: 10.1016/j.metabol.2022.155141

Fig. 6.

Fig. 6.

Central blockade of GRK2 partially recues pubertal delay caused by postnatal undernutrition in female rats. Female rats reared in large litters (LL) were icv injected with GRK2 inhibitor, βARK1-I, or vehicle every 12 h, from PND25 to PND37. Reference values from control (NL) females icv injected with vehicle (VEH) served as controls; these are shown as grey symbols. The parameters presented are: body weight (A), daily food intake (FI; panel B), cumulative percentage of vaginal opening (VO; panel C) and first estrus (D). In addition, uterus (E) and ovary (F) weights, as well as LH (G) and FSH (H) levels are shown, together with the histological score of follicular development/ovulation (Pub-score; panel I), and the mean age of expected first ovulation, calculated on the basis of the stage follicular maturation (J). Data represent mean ± SEM (N = 10/group). *P < 0.05 vs. the LL group treated with vehicle (ANOVA followed by Student–Newman–Keuls multiple range tests). Data represent mean ± SEM. *P < 0.05, ***P < 0.001 vs VEH LL. #P < 0.05, ##P < 0.01, ###P < 0.001 vs VEH NL.