Table 1. Effect of Oral Administration of Baikiain (1g/kg) in ND4 Male Mice on Parameters of Acute Toxicitya.
| 0 h |
2 h-Post treatment |
4 h-Post treatment |
6 h-Post treatment |
|||||
|---|---|---|---|---|---|---|---|---|
| Control | Baikiain | Control | Baikiain | Control | Baikiain | Control | Baikiain | |
| ALT (U/L) | 34(1.8) | 31(0.90) | 48(2.7) | 81(10.0)* | 59(3.1) | 190(71)* | 66(3.9) | 230(81)* |
| BUN (mg/dL) | 22(1.0) | 21(1.3) | 24(1.1) | 27(2.0) | 32(1.2) | 42(2.7)* | 33(1.6) | 61(3.7)† |
| CRE (mg/dL) | 0.22(0.013) | 0.24(0.024) | 0.24(0.016) | 0.34(0.053) | 0.25(0.027) | 0.58(0.11)* | 0.2(0.00) | 0.63(0.075)* |
| ALB (g/dL) | 4.2(0.072) | 4.0(0.089) | 3.8(0.094) | 3.6(0.094) | 3.7(0.083) | 3.6(0.14) | 3.5(0.071) | 3.3(0.12) |
| ALP (U/L) | 136(9.9) | 129(6.2) | 128(9.6) | 110(4.9) | 123(7.1) | 122(6.2) | 115(5.5) | 118(5.1) |
| TBIL (mg/dL) | 0.30(0.0) | 0.30(0.0) | 0.30(0.0) | 0.29(0.011) | 0.30(0.0) | 0.27(0.017) | 0.28(0.013) | 0.26(0.016) |
| AMY (U/L) | 1100(45) | 1200(53) | 1200(27) | 1300(78) | 1300(36) | 1600(95)* | 1198(42.69) | 1532(131.8)¶ |
| GSH (μg/mg) in liver tissue | 675(49) | 207(61)† | ||||||
a
Values are means ± SEM, n = 10 mice per group. Two-tailed t test comparisons (¶p < 0.05, *p < 0.01, †p < 0.001).