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. 2023 Jun 4;13(10):3434–3450. doi: 10.7150/thno.81951

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HIIT alleviates neuronal damage induced by STZ administration. (A) Representative confocal microscopy images of MAP2. The acquired images of MAP2 were thresholded, median filtered, and binarized using Image J software. The MAP2 segments were size-separated from the continuous structure to small particles. The number of different sizes of particles was analyzed. MAP2 intensity was analyzed as a percentage of control. The scale bar represents 10 μm. The MAP2 segments were area-separated and analyzed. (B) Representative confocal microscopy images of MBP. MBP intensity was calculated as a percentage of control. (C) Representative immunofluorescence images of synaptophysin (SYP, red, presynaptic marker) and spinophilin (Spin, green, dendritic spine marker). Line-scan analysis was performed to analyze the colocalization of spinophilin and synaptophysin. Immunoactivity intensity analyses of spinophilin and synaptophysin and the colocalized puncta between the two channels were qualified and analyzed using Image J software. The scale bar represents 10 μm. Data represent mean ± SEM, n = 12 slices from 6 animals. ^*P < 0.05 vs. Cont group, ^#P < 0.05 vs. STZ group.