Table 4.
Effects of cell-laden biomaterials on MSCs osteogenic differentiation induced by external mechanical stimulation
| Loading | Loading Regime | Scaffold | Osteogenesis | Ref |
|---|---|---|---|---|
| Compression | 42%, 0.3Hz, 3h/day for 21 days | GelMA | ALP, RUNX2, OCN, OPN, Mineral deposition (+) | 140 |
| 5-10%, 1Hz, 8h/day for 6 days | Collagen | BMP-2 (+) RUNX2, Col-1 (-) |
142 | |
| 5-20%, 1Hz, 2h/day for 28 days | Poly(ε-caprolactone) | RUNX2 (+) COL1A1 (-) |
139 | |
| 20-60%, 0.75Hz, 4h/day for 7 days | Octacalcium phosphate-gelatin | OCN, OPN, Col-1 (+) | 143 | |
| Stretching | 10%, 1Hz, 4h/day for 21 days | Fibrin hydrogel | ACAN, SOX9, BMP-2, RUNX2, OPN, COL1A1 (+) ALP (-) |
144 |
| Perfusion | 3ml/min (0.2 dynes/cm2) for 14 days | HA-PLGA | IBSP (+) | 145 |
| 7ml/min for 6 weeks | Alginate and gelatin-based hydrogel | Mineral deposition (+) | 146 | |
| 1ml/min, 30min/day for 3 weeks | Collagen-HA | OCN, OPN, Collagen, Mineral deposition (+) | 147 | |
| 0.8ml/min, 8h/day for 21 days | LTMC | Collagen, ALP (+) | 148 | |
| 6.3 cm3 min-1 for 0-2 weeks in the standard medium and 0-2 weeks in a differentiation medium | Apatite-Fiber | ALP, Calcification (+) | 149 | |
| 1.7ml/min, 5min every 15 min/day for 21 days | RCP, MgAp | Cell viability (+) | 150 | |
| 116μm/s for 21 days | Collagen coated with Mg -doped HA | ALP, OCN, OPN, BMP-2 (+) | 151 | |
| 3μl/min, 6h /day for 7 days | HA (750-900μm) |
ALP (+) | 51 | |
| 10ml/min for 14 days | Fibrin breads | OPN, RUNX2, VEGF (+) | 152 | |
| 1.7ml/min for 21 days | Chitsan/HA | Collagen, Osteocalcin, Calcium deposition (+) | 153 | |
| 2ml/min for 14 days | HA-PCL | ALP, RUNX2 (+) | 154 | |
| Rotating, perfusion and compression | 0.22%, 1Hz, 5rpm /min, 4h/day for 2 weeks | PCL/TCP | RUNX2, COL1A1 (+) | 155 |
| Vibration | 30nm amplitude, 1000Hz for 21 days | Collagen | RUNX2, Collagen, ALP, OCN, OPN, BMP-2 (+) | 156 |
| 90nm amplitude, 1000Hz for 9 days | Collagen | RUNX2, OSX, ALP, OCN, OPN, ON (+) | 157 | |
| 30nm amplitude, 1000Hz for 3 weeks | Collagen | RUNX2, OSX, OPN, OCN, ALP (+) | 138 |