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. 2023 Jun 12;13(10):3467–3479. doi: 10.7150/thno.82873

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Ldlr aptamer promotes Ldlr mRNA sorting into CD9-MCP-engineered EVs: (A) Schematic illustration of Ldlr mRNA enriched in CD9-MCP-engineered EVs. Ldlr-expressing vector, Ldlr aptamer, and CD9-MCP vector were simultaneously transfected into HEK293T cells. Ldlr mRNA was expressed by the Ldlr-expressing vector and recognized by the Ldlr aptamer, preventing translation. The Ldlr aptamer promoted Ldlr mRNA enrichment in CD9-MCP-engineered EVs through MS2/MCP binding. (B) qPCR analysis of Ldlr mRNA in EVs derived from cells treated as indicated. Data are presented as mean±SEM of 3 independent experiments. *P<0.05 one-way ANOVA.