Abstract
Pizotifen is a clinically effective anti-migraine agent with potent anti-serotonin and anti-histamine properties. Pizotifen is equipotent in blocking contractions of the canine basilar artery induced by serotonin, norepinephrine or calcium chloride. As a result, the primary action of pizotifen in the canine basilar artery system appears to be calcium channel blockade and not selective antagonism of serotonin or norepinephrine. Calcium channel blocking ability may be related to the clinical efficacy of pizotifen in the treatment of migraine.
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Selected References
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- Allen G. S., Gross C. J., Henderson L. M., Chou S. N. Cerebral arterial spasm. Part 4: in vitro effects of temperature, serotonin analogues, large nonphysiological concentrations of serotonin, and extracellular calcium and magnesium on serotonin-induced contractions of the canine basilar artery. J Neurosurg. 1976 May;44(5):585–593. doi: 10.3171/jns.1976.44.5.0585. [DOI] [PubMed] [Google Scholar]
- Amery W. K. Flunarizine, a calcium channel blocker: a new prophylactic drug in migraine. Headache. 1983 Mar;23(2):70–74. doi: 10.1111/j.1526-4610.1983.hed2302070.x. [DOI] [PubMed] [Google Scholar]
- Diamond S., Schenbaum H. Flunarizine, a calcium channel blocker, in the prophylactic treatment of migraine. Headache. 1983 Jan;23(1):39–42. doi: 10.1111/j.1526-4610.1983.hed2301039.x. [DOI] [PubMed] [Google Scholar]
- Gelmers H. J. Nimodipine, a new calcium antagonist, in the prophylactic treatment of migraine. Headache. 1983 May;23(3):106–109. doi: 10.1111/j.1526-4610.1983.hed2303106.x. [DOI] [PubMed] [Google Scholar]
- Hardebo J. E., Edvinsson L., Owman C., Svendgaard N. A. Potentiation and antagonism of serotonin effects on intracranial and extracranial vessels. Possible implications in migraine. Neurology. 1978 Jan;28(1):64–70. doi: 10.1212/wnl.28.1.64. [DOI] [PubMed] [Google Scholar]
- Leysen J. E. Serotoninergic receptors in brain tissue: properties and identification of various 3H-ligand binding sites in vitro. J Physiol (Paris) 1981;77(2-3):351–362. [PubMed] [Google Scholar]
- Louis P. A double-blind placebo-controlled prophylactic study of flunarizine (Sibelium) in migraine. Headache. 1981 Nov;21(6):235–239. doi: 10.1111/j.1526-4610.1981.hed2106235.x. [DOI] [PubMed] [Google Scholar]
- Lowe D. A., Matthews E. K., Richardson B. P. The calcium antagonistic effects of cyproheptadine on contraction, membrane electrical events and calcium influx in the guinea-pig taenia coli. Br J Pharmacol. 1981 Nov;74(3):651–663. doi: 10.1111/j.1476-5381.1981.tb10476.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meyer J. S., Hardenberg J. Clinical effectiveness of calcium entry blockers in prophylactic treatment of migraine and cluster headaches. Headache. 1983 Nov;23(6):266–277. doi: 10.1111/j.1526-4610.1983.hed2306266.x. [DOI] [PubMed] [Google Scholar]
- Solomon G. D., Steel J. G., Spaccavento L. J. Verapamil prophylaxis of migraine. A double-blind, placebo-controlled study. JAMA. 1983 Nov 11;250(18):2500–2502. [PubMed] [Google Scholar]
- Speight T. M., Avery G. S. Pizotifen (BC-105): a review of its pharmacological properties and its therapeutic efficacy in vascular headaches. Drugs. 1972;3(3):159–203. doi: 10.2165/00003495-197203030-00002. [DOI] [PubMed] [Google Scholar]