Fig. 1.

Restored estrous cycle in the MSC-injected POI mouse model. Three different numbers of MSCs (MSC-10K: 10,000 cells/100 µL, MSC-100K: 100,000 cells/100 µL, and MSC-1M: 1,000,000 cells/100 µL) were injected intravenously. A Representative image of the proestrus, estrus, metestrus, and diestrus phases in mouse vaginal smear samples. Animal shows significantly delayed cycle (> 95% CI) is highlighted with ǂ symbol. B The estrous cycle length in each mouse after MSC treatment. C Representation of the estrous cycle change in mice by daily vaginal smear analysis