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. 2023 Jun 20;14:165. doi: 10.1186/s13287-023-03397-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Restored ovarian function by MSC treatment. A Representative mouse ovarian tissue image stained with H&E. B Average size of the mouse ovaries in healthy mice (control), untreated POI mice (POI), and MSC-treated POI mice (MSC) (n = 3 per group). C–E Average serum E2, AMH, and FSH levels in the control, POI, and MSC groups (n = 3 per group). F Number of ovarian follicles in the control, POI, and MSC groups. Primordial/primary follicles, secondary follicles, preantral/antral follicles, and corpus lutea were differentially counted and merged into one stacked bar (n = 3 per group)