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. 2023 Jun 20;14:165. doi: 10.1186/s13287-023-03397-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Fertility was restored by MSC treatment in the POI mouse model (n = 6 per group). A Pregnancy rate comparison between healthy mice (control), untreated POI mice (POI), and MSC-treated POI mice (MSC) in the first breeding experiment. B Pregnancy rate comparison between the control group, POI group, and MSC group in the second breeding experiment. C Average number of delivered pups per litter. D Representative image of delivered pups at Day 0. E Genomic DNA PCR analysis for detecting injected cells (human MSCs) in mouse whole blood using human-specific ALU primers (n = 3 per group). F Genomic DNA PCR analysis for detecting injected cells in neonatal offspring liver tissue using human-specific ALU primers (n = 5 per group). Data are presented as the mean ± SD. (Significance level, *p < 0.05, **p < 0.005, ***p < 0.0005, ****p < 0.0001; NS: Not significant.)