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. 2023 Jun 20;11:100. doi: 10.1186/s40478-023-01598-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Myelinated axons in CGM and NAGM have a similar g-ratio and axon size distribution. A Representative scanning electron microscopic images (STEM) images of post-mortem control grey matter (CGM) of control donors (from donor CM 2) and normal appearing grey matter (NAGM) of donors with progressive MS (from donor NAM 6). Top: overview images. Bottom: detailed images from boxed regions in top images. Scale bars represent 2 µm (top images) or 0.5 µm (bottom images). B Violin plots depict the distribution of g-ratio (r/R). Datapoints represent mean per donor (● = female (SPMS), ▲ = male (SPMS), △ = male (PPMS), color-coded, see Table 1) and boxplots show the median and inter quartile range (IQR). C Scatter plot showing the g-ratio versus axon radius (log-linear fit). D Histogram with kernel density estimation of the axon radius (r). Number of control donors (CWM) is 4, number of donors with progressive MS (NAWM) is 6, and 100–200 myelinated axons per donor were analysed. Statistics were performed using a linear mixed model (B) or unpaired Student’s t test (D)