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. 2023 Jun 21;2023(6):CD014788. doi: 10.1002/14651858.CD014788.pub2

Comparison 3. GnRHas versus danazol.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
3.1 Relief of overall pain ‐ dichotomous 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1.1 Pelvic tenderness, partly resolved ‐ 6 months 1 41 Risk Ratio (M‐H, Fixed, 95% CI) 1.15 [0.49, 2.73]
3.1.2 Pelvic tenderness, complete resolved ‐ 6 months 1 41 Risk Ratio (M‐H, Fixed, 95% CI) 1.10 [0.67, 1.81]
3.2 Relief of overall pain ‐ continuous 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
3.2.1 Relief of overall pain‐ 3 months 1 41 Mean Difference (IV, Fixed, 95% CI) ‐0.30 [‐1.66, 1.06]
3.2.2 Pelvic pain ‐ 3 months 1 41 Mean Difference (IV, Fixed, 95% CI) 0.20 [‐0.26, 0.66]
3.2.3 Dysmenorrhoea ‐ 3 months 1 41 Mean Difference (IV, Fixed, 95% CI) 0.10 [‐0.49, 0.69]
3.2.4 Dyspareunia ‐ 3 months 1 41 Mean Difference (IV, Fixed, 95% CI) ‐0.20 [‐0.77, 0.37]
3.2.5 Pelvic induration ‐ 3 months 1 41 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.59, 0.39]
3.2.6 Pelvic tenderness ‐ 3 months 1 41 Mean Difference (IV, Fixed, 95% CI) ‐0.20 [‐0.78, 0.38]
3.2.7 Relief of overall pain ‐ 6 months 1 41 Mean Difference (IV, Fixed, 95% CI) 0.40 [‐0.86, 1.66]
3.2.8 Pelvic pain ‐ 6 months 1 41 Mean Difference (IV, Fixed, 95% CI) 0.50 [0.10, 0.90]
3.2.9 Dysmenorrhoea ‐ 6 months 1 41 Mean Difference (IV, Fixed, 95% CI) 0.40 [‐0.12, 0.92]
3.2.10 Dyspareunia ‐ 6 months 1 41 Mean Difference (IV, Fixed, 95% CI) ‐0.40 [‐0.90, 0.10]
3.2.11 Pelvic induration ‐ 6 months 1 41 Mean Difference (IV, Fixed, 95% CI) 0.70 [0.21, 1.19]
3.2.12 Pelvic tenderness ‐ 6 months 1 41 Mean Difference (IV, Fixed, 95% CI) ‐0.20 [‐0.75, 0.35]
3.3 Adverse effects ‐ dichotomous 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.3.1 Vaginal dryness/vaginitis ‐ 6 months 1 59 Risk Ratio (M‐H, Fixed, 95% CI) 1.45 [0.52, 4.05]
3.3.2 Hot flushes/flashes ‐ 6 months 1 59 Risk Ratio (M‐H, Fixed, 95% CI) 15.50 [0.93, 259.61]
3.3.3 Gastrointestinal ‐ 6 months 1 59 Risk Ratio (M‐H, Fixed, 95% CI) 0.15 [0.01, 2.74]
3.3.4 Weight gain ‐ 6 months 1 59 Risk Ratio (M‐H, Fixed, 95% CI) 0.26 [0.08, 0.82]
3.3.5 Acne ‐ 6 months 1 59 Risk Ratio (M‐H, Fixed, 95% CI) 0.08 [0.00, 1.35]
3.3.6 Generalised spasm ‐ 6 months 1 59 Risk Ratio (M‐H, Fixed, 95% CI) 0.08 [0.00, 1.35]