| 8.1 Relief of overall pain ‐ continuous |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 8.1.1 Dysmenorrhoea, visual analog scale ‐ 3 months |
1 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
Not estimable |
| 8.1.2 Dysmenorrhoea, verbal rating scale ‐ 3 months |
1 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
Not estimable |
| 8.1.3 Dyspareunia, visual analog scale ‐ 3 months |
1 |
52 |
Mean Difference (IV, Fixed, 95% CI) |
1.39 [0.04, 2.74] |
| 8.1.4 Dyspareunia, verbal rating scale ‐ 3 months |
1 |
52 |
Mean Difference (IV, Fixed, 95% CI) |
0.28 [‐0.12, 0.68] |
| 8.1.5 Non‐menstrual pain, visual analog scale ‐ 3 months |
1 |
55 |
Mean Difference (IV, Fixed, 95% CI) |
0.49 [‐0.59, 1.57] |
| 8.1.6 Non‐menstrual pain, verbal rating scale ‐ 3 months |
1 |
55 |
Mean Difference (IV, Fixed, 95% CI) |
0.04 [‐0.36, 0.44] |
| 8.1.7 Dysmenorrhoea, visual analog scale ‐ 6 months |
1 |
55 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.82 [‐1.49, ‐0.15] |
| 8.1.8 Dysmenorrhoea, verbal rating scale ‐ 6 months |
1 |
55 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.35 [‐0.58, ‐0.12] |
| 8.1.9 Dyspareunia, visual analog scale ‐ 6 months |
1 |
52 |
Mean Difference (IV, Fixed, 95% CI) |
1.17 [0.25, 2.09] |
| 8.1.10 Dyspareunia, verbal rating scale ‐ 6 months |
1 |
52 |
Mean Difference (IV, Fixed, 95% CI) |
0.33 [0.04, 0.62] |
| 8.1.11 Non‐menstrual pain, visual analog scale ‐ 6 months |
1 |
55 |
Mean Difference (IV, Fixed, 95% CI) |
0.41 [‐0.94, 1.76] |
| 8.1.12 Non‐menstrual pain, verbal rating scale ‐ 6 months |
1 |
55 |
Mean Difference (IV, Fixed, 95% CI) |
0.15 [‐0.20, 0.50] |
| 8.2 Bone mineral density of spinal bone mass ‐ continuous |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 8.2.1 Percentage change values ‐ 6 months |
1 |
41 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.96 [‐3.62, ‐0.30] |
| 8.2.2 Percentage change values ‐ 12 months |
1 |
41 |
Mean Difference (IV, Fixed, 95% CI) |
‐5.10 [‐7.39, ‐2.81] |
| 8.3 Adverse effects ‐ dichotomous |
1 |
|
Risk Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 8.3.1 Hot flushes/flashes ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.29 [1.21, 4.32] |
| 8.3.2 Headache ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.41 [0.51, 11.38] |
| 8.3.3 Asthenia ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.24 [0.03, 2.02] |
| 8.3.4 Mood change ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.45 [0.26, 7.99] |
| 8.3.5 Dermatitis ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.14 [0.01, 2.55] |
| 8.3.6 Dizziness‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.48 [0.05, 5.01] |
| 8.3.7 Joint pain‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.48 [0.05, 5.01] |
| 8.3.8 Drowsiness ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.48 [0.05, 5.01] |
| 8.3.9 Swelling ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.19 [0.01, 3.85] |
| 8.3.10 Nausea‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.48 [0.05, 5.01] |
| 8.3.11 Tachycardia ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.48 [0.05, 5.01] |
| 8.3.12 Vaginal dryness ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
4.83 [0.24, 96.16] |
| 8.3.13 Insomnia ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.32 [0.01, 7.57] |
| 8.3.14 Hypertrichosis ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.32 [0.01, 7.57] |
| 8.3.15 Seborrhea‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.32 [0.01, 7.57] |
| 8.3.16 Skin rash ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.32 [0.01, 7.57] |
| 8.3.17 Constipation ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.32 [0.01, 7.57] |
| 8.3.18 Itching ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.90 [0.12, 68.15] |
| 8.3.19 Vaginal discharge ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.90 [0.12, 68.15] |
| 8.3.20 Paresthesia ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.90 [0.12, 68.15] |
| 8.3.21 Cramps ‐ 6 months |
1 |
55 |
Risk Ratio (M‐H, Fixed, 95% CI) |
2.90 [0.12, 68.15] |
