Minaguchi 1986.

Study characteristics
Methods	Trial design: Randomised, multi‐centre study
Participants	Participants: 191 women were randomised and analysed. Mean age: not stated Inclusion criteria:  Laparoscopically diagnosed endometriosis  Over 18 years old patients who have received hormonal therapy  Patients with persistent diagnosed endometriosis postoperatively  Exclusion criteria:  Patients receiving conservative surgery  Setting: Japan  Timing: not stated
Interventions	Buserelin 300 mcg once daily intranasally for 6 months (n = 69)  versus  Buserelin 300 mcg twice daily intranasally for 6 months (n = 59)  versus Buserelin 300 mcg three times a day intranasally for 6 months (n = 63)
Outcomes	Relief of overall pain: Intermenstrual abdominal pain, lumbago, dyspareunia, pain on defecation, pelvic tenderness Adverse effects Flexibility of the uterus Nodules in the posterior cul‐de‐sac Endometrial cyst
Notes	Intention‐to‐treat analysis: not stated Sample size calculation: not stated Funding:  not stated Note previous version: Authors contacted regarding methods and data; awaiting response
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details were provided of method used to generate the randomisation sequence.
Allocation concealment (selection bias)	Unclear risk	"Envelope". No further details were provided of method used to conceal treatment group allocation.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information about blinding; open‐label study
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information about blinding; open‐label study
Incomplete outcome data (attrition bias) All outcomes	Low risk	All women who were randomised were analysed.
Selective reporting (reporting bias)	Low risk	The study protocol was not available but it was clear that the published reports included all expected outcomes, including those that were prespecified.
Other bias	Low risk	No other risk of bias detected