Odukoya 1995.

Study characteristics
Methods	Trial design: Randomised study
Participants	Participants: 21 women were randomised and analysed. Mean age: 33 ± 5 years Inclusion criteria: Laparoscopically diagnosed endometriosis Pelvic pain Exclusion criteria: not stated Setting: United Kingdom Timing: not stated
Interventions	Leuprolide acetate 3.75 SC monthly for 3 months (n = 10) versus Danazol 400 mg daily PO for 3 months (n = 11)
Outcomes	Relief of overall pain (Biberoglu + Behrman scale) Serum soluble CD23
Notes	Intention‐to‐treat analysis: Yes Sample size calculation: not stated Funding: not stated Note previous version: Authors contacted regarding methods (blinding) and SD data; awaiting response
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomisation was "computer generated". No further details of method used to generate the randomisation sequence were provided.
Allocation concealment (selection bias)	Low risk	"concealed in an envelope only opened at commencement of treatment". No further details of method used to conceal allocation were provided.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No details provided of blinding of participants or trial personnel
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No details provided of blinding of outcome assessment
Incomplete outcome data (attrition bias) All outcomes	Low risk	No losses to follow‐up
Selective reporting (reporting bias)	Low risk	The study protocol was not available but it was clear that the published reports included all expected outcomes, including those that were prespecified.
Other bias	Low risk	No other risk of bias detected