Table 2. Characteristics of the selected studies.
| Authors | Number of subjects (age) | Sample distribution | Cancer therapy | OM diagnosis criteria according to |
|---|---|---|---|---|
| Lalla 2020 | 108 (>18 y.o) | 55 Dentoxol 53 Control | RT | WHO |
| Soltani 2020 | 46 (18-65 y.o) | 23 Plantago major syrup 23 Control | RT | WHO |
| Chaitanya 2020 | 75 (>18 y.o) | 25 Topical 5% zinc oxide paste 25 Improvised zinc (1%) 25 Control | RT CT | WHO |
| Immonen 2020 | 45 (2-18 y.o) | 24 Caphosol 21 Control | CT | WHO |
| Sun 2019 | 100 (24-67 y.o) | 50 Vitamin B + GeneTime 50 Vitamin B (control). | RT | RTOG |
| Sio 2019 | 275 (>18 y.o) | 78 Doxepin 76 Diphenhydramine- lidocaine-antacid 76 Control | RT | RTOG |
| Huang 2019 | 64 (35-75 y.o) | 31 L- Glutamine 33 Control | RT | CTCAE (Definition OM) |
| Legouté 2019 | 83 (18-75 y.o) | 42 LLL-T/ PBM-T 41 Control | CT | WHO |
| Charambolous 2018 | 72 (>18 y.o) | 36 Thyme honey 36 Control | RT CT CT + surgery | RTOG |
| Huang 2018 | 91 (>20 y.o) | 48 SMR/EP 43 Control | CT RT | WHO |
| Gobbo 2018 | 101 (3-18 y.o) | 51 PBM 50 Control. | CT | WHO |
| Cabrera-Jaime 2017 | 50 (>18 y.o) | 15 Sodium SB 5% + Plantago major 19 SB 5% + CMW 0.12% 16 Control | CT | WHO |
| Medeiros 2017 | 36 (3-16 y.o) | 18 LLL-T 18 LLL-T + PC-T | CT RT | Non mentioned |
| Erden 2017 | 90 (17-66 y.o) | 30 CMW 30 OC-T 30 Control *All received antibiotics for oral ulcerations. | CT | WHO |
| Wong 2017 | 215 (>18 y.o) | 108 Caphosol 107 Control | RT CT | Non mentioned |
| Mohammadi 2021 | 144 (>18 y.o) | 48 Zinc chloride 0.2% 48 SB 5% 48 Control | CT | WHO |
| Yin 2022 | 87 (18-80 y.o) | 44 RADoralex 43 Control | RT CT | WHO |
| Javad Kia 2021 | 50 (>18 y.o) | 25 Curcumin nanomicelle 80 mg 25 Control | RT CT |
WHO |
OM: oral mucositis; y.o: years old; RT: radiotherapy; WHO: World Health Organization; CT: chemotherapy; RTOG: Radiation Therapy Oncology Group; PBM-T: photobiomodulation therapy; PD-T: photodynamic therapy; CTCAE: Common Terminology Criteria for Adverse Events; LLL-T: Low-Level Laser therapy; SB: sodium bicarbonate; SMR: saline mouth rinses; EP: education program; SC: standard care; CMW: chlorhexidine mouthwash; PC-T: photochemotherapy; OC-T: oral cryotherapy.