Table 3. OM Treatment and results of the selected studies.
| Authors | OM Treatment | Variables | Results |
|---|---|---|---|
| Lalla 2020 | Dentoxol | Incidence and OM severity Duration of severe OM Pain due to OM | Proportion of severe OM patients at 3-6 weeks after treatment was significantly lower in the dentoxol group vs. control. No significant difference in the other variables evaluated. |
| Soltani 2020 | Plantago major (syrup) | OM severity Pain intensity | Severity of OM and pain was significantly lower in the Plantago major group. |
| Chaitanya 2020 | Zinc oxide Improvised zinc | OM severity | Severity of OM was significantly lower in both zinc group vs. control. No significant difference between improvised zinc group and zinc oxide group. |
| Immonen 2020 | Caphosol | OM severity Patient-reported oral symptoms. | No significant difference between caphosol and control. |
| Sun 2019 | Vitamin B + GeneTime Vitamin B alone | Ulcer area Pain intensity Healing time. | Severity of OM was lower in the Vitamin B+ Genetime group. Significantly more ulcers healed in 1- 2 weeks in Vitamin B+ Genetime group vs. control, but not at 3 weeks. |
| Sio 2019 | Doxepina Diphenhydramine- lidocaine-antacid | Pain reduction | The pain reduction was significantly greater in the doxepin group and lidocaine group vs. control. The stinging and burning were significantly higher in the doxepin group vs. control. |
| Huang 2019 | L- Glutamine | OM severity | L-glutamine significantly decreased the mean maximum severity of OM vs. control. Significantly more patients in control group developed OM. |
| Legouté 2019 | LLL-T/ PBM-T | OM severity Nutritional status Pain intensity | No significant difference in OM severity, nutritional status or pain between LLL-T and control. |
| Charambolous 2018 | Thyme honey | OM severity Symptoms and signs severity Quality of life. | OM severity and weight loss were significantly lower in the thyme honey vs. control. Quality of life was significantly higher in thyme honey vs. control. |
| Huang 2018 | SMR/EP | OM severity Symptoms score Quality of Life | Physical and socio-emotional quality of life was significantly higher in SMR/EP vs. control at 8 weeks. Severity and symptoms of OM were not different between the groups. |
| Gobbo 2018 | PBM | OM severity Pain intensity | OM severity was significantly lower in the PBM vs. control. Pain reduction was significantly higher in the PBM vs. control. |
| Cabrera-Jaime 2017 | SB 5% + Plantago major SB 5% + CMW 0.12% Double SB 5% aqueous solution | Healing time Pain intensity Oral intake capacity Quality of life. | No significant differences in the variables evaluated between the groups. |
| Medeiros 2017 | LLLT LLLT + PCT | OM lip lesion area (cm2) | LLLT + PCT group showed significantly smaller lesion areas vs. LLL-T alone. |
| Erden 2017 | CMW OCT | OM severity Transition time to oral nutrition. | Transition time from oral nutrition in the chlorhexidine group was significantly shorter than in other groups. |
| Wong 2017 | Caphosol | OM severity Duration of OM Incidence and duration of severe dysphagia pain Quality of life. | No significant difference in the variables evaluated between the groups. |
| Mohammadi 2021 | sodium bicarbonate mouthwash zinc chloride mouthwash | OM severity Quality of life
|
OM severity was significantly lower in both groups vs. placebo. Quality of life was significantly higher in both groups vs. placebo. |
OM: oral mucositis; PBM-T: photobiomodulation therapy; LLL-T: Low-Level Laser therapy; SB: sodium bicarbonatum; SMR: saline mouth rinses; EP: education program; CMW: chlorhexidine mouthwash; PC-T: photochemotherapy; OC-T: oral cryotherapy.