TABLE 1.
Potency of CVM-1118 and its active metabolite, CVM-1125, in human cancer cell lines.
| IC50 (nM) | |||
|---|---|---|---|
| Cell lines | Cancer type | CVM-1118 | CVM-1125 |
| A549 | Lung | 26 | 29 |
| DU-145 | Prostate | 21 | 27 |
| HT-29 | Colon | 15 | 17 |
| MDA-MB-231 | Breast | 18 | 14 |
| MDA-MB-435 a | Melanoma | 4 | 5 |
| Mia PaCa-2 | Pancreatic | 11 | 7 |
| NCI-ADR-RES | Ovarian | 14 | 14 |
| SK-N-MC | Neuroblastoma | 9 | 8 |
| U118MG | Glioma | 10 | 8 |
Cytotoxicity assays performed in nine human cancer cell lines using both CVM-1118 and CVM-1125.
a
MDA-MB-435 cells are now confirmed of melanoma origin and are derived from M14 melanoma cell line.