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Effect of CVM-1118 on cell cycle distribution in HT-29 cells after CVM-1118 treatment for 48 h.
| Cell cycle profile (%) | ||||||
|---|---|---|---|---|---|---|
| Test article | Sub-G1 | G1 phase | S phase | G2/M phase | EndoR | |
| Vehicle Control | 1.06 | 51.93 | 22.17 | 23.91 | 1.36 | |
| CVM-1118 | 10 nM | 1.24 | 49.34 | 23.02 | 25.66 | 1.28 |
| 30 nM | 1.44 | 50.63 | 23.30 | 23.71 | 1.23 | |
| 100 nM | 26.96 | 16.27 | 10.90 | 43.42 | 2.84 | |
| 300 nM | 22.46 | 1.58 | 23.63 | 50.77 | 2.45 | |
