Table 3.
Association of advanced age with CRCs categorized by mismatch repair deficiency, BRAF p.V600E mutation and APC mutations.
| Total | >80 y a | 70-79 y a | 60-69 y a | 50-59 y a | 40-49 y a | <40 y a | ||
|---|---|---|---|---|---|---|---|---|
| (n=544) | (n=60) | (n=109) | (n=132) | (n=119) | (n=85) | (n=39) | P-value | |
| dMMR | 73 (13%) | 21 (35%) | 18 (17%) | 8 (6.1%) | 12 (10%) | 9 (11%) | 5 (13%) | |
| BRAF + APC + | 8 (1.5%) | 3 (5.0%) | 2 (1.8%) | 1 (0.8%) | 2 (1.7%) | 0 | 0 | 0.18 |
| BRAF + APC - | 27 (5.0%) | 11 (18%) | 10 (9.2%) | 4 (3.0%) | 1 (0.8%) | 1 (1.2%) | 0 | <0.001 |
| BRAF - APC + | 24 (4.4%) | 2 (3.3%) | 3 (2.8%) | 2 (1.5%) | 7 (5.9%) | 6 (7.1%) | 4 (10%) | 0.12 |
| BRAF - APC - | 14 (2.6%) | 5 (8.3%) | 3 (2.8%) | 1 (0.8%) | 2 (1.7%) | 2 (2.4%) | 1 (2.6%) | 0.07 |
| pMMR | 471 (87%) | 39 (65%) | 91 (83%) | 124 (94%) | 107 (90%) | 76 (89%) | 34 (87%) | |
| BRAF + APC + | 3 (0.6%) | 0 | 0 | 1 (0.8%) | 1 (0.8%) | 0 | 1 (2.6%) | 0.47 |
| BRAF + APC - | 24 (4.5%) | 7 (12%) | 6 (5.5%) | 5 (3.8%) | 5 (4.2%) | 1 (1.2%) | 0 | 0.04 |
| BRAF - APC + | 363 (67%) | 26 (43%) | 70 (64%) | 93 (70%) | 87 (73%) | 60 (71%) | 27 (69%) | 0.002 |
| BRAF - APC - | 81 (15%) | 6 (10%) | 15 (14%) | 25 (19%) | 14 (12%) | 15 (18%) | 6 (15%) | 0.5 |
BRAF+, BRAF p.V600E mutation; dMMR, mismatch repair deficiency; pMMR, mismatch repair proficiency.
a
At diagnosis of colorectal cancers.