Differential co-expression networks predictive of any metastasis, stratified by three tissue architectures (Intra, Inter, and Away). C indicates whether co-expression was conserved between patients with and without metastasis; D indicates whether co-expression differed between patients with and without metastasis; and S indicates whether significant co-expression was specific to either patients with or without metastasis. Edges between markers indicate whether relationship could be characterized by C, D or S. Intra, Inter, and Away are described in Data Acquisition and Preprocessing.