Supplemental Figure S4.

Box plots and beeswarm scatterplots of select protein marker expression for biomarkers predictive of distant metastasis, stratified by mismatch repair (MMR) status: granzyme B (GZMB) inside the tumor (Intra; A); GZMB at the interface (Inter; B); CD11c away from tumor (Away; C); and Ki-67 away from tumor (D). Marker expression plotted in beeswarm plots was filtered on the basis of detection of outliers using a modified Tukey outlier test—after this initial filtering, only points between the 10% and 90% quantiles for each stratum were included. Intra, Inter, and Away are described in Data Acquisition and Preprocessing. dMMR, MMR deficient; pMMR, MMR proficient.