Table 1.

Associations of obesity metrics (as continuous variables) with incident CVDs and mortality outcomes

Incident disease	BMI (log)			WHR
	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3
Any CVD	1.33*	1.30*	1.22*	1.38*	1.33*	1.22*
	[1.32, 1.34]	[1.29, 1.32]	[1.20, 1.23]	[1.37, 1.40]	[1.31, 1.34]	[1.20, 1.23]
	<1.0 × 10−300	<1.0 × 10−300	<1.0 × 10−300	<1.0 × 10−300	<1.0 × 10−300	7.05 × 10−225
Ischaemic heart disease	1.33*	1.29*	1.18*	1.46*	1.38*	1.24*
	[1.31, 1.34]	[1.27, 1.30]	[1.16, 1.19]	[1.44, 1.48]	[1.36, 1.40]	[1.22, 1.26]
	<1.0 × 10−300	<1.0 × 10−300	1.89 × 10−155	<1.0 × 10−300	<1.0 × 10−300	3.17 × 10−166
Atrial fibrillation	1.36*	1.35*	1.27*	1.30*	1.27*	1.18*
	[1.35, 1.38]	[1.33, 1.37]	[1.25, 1.28]	[1.28, 1.32]	[1.25, 1.29]	[1.16, 1.20]
	<1.0 × 10−300	<1.0 × 10−300	3.11 × 10−281	8.66 × 10−239	2.85 × 10−190	1.04 × 10−80
Heart failure	1.59*	1.52*	1.34*	1.67*	1.54*	1.33*
	[1.57, 1.62]	[1.49, 1.54]	[1.32, 1.37]	[1.64, 1.71]	[1.51, 1.57]	[1.30, 1.36]
	<1.0 × 10−300	<1.0 × 10−300	3.43 × 10−237	<1.0 × 10−300	<1.0 × 10−300	7.38 × 10−132
All-cause mortality	1.17*	1.12*	1.05*	1.39*	1.28*	1.19*
	[1.16, 1.18]	[1.11, 1.14]	[1.03, 1.06]	[1.37, 1.41]	[1.27, 1.30]	[1.18, 1.21]
	1.51 × 10−174	4.74 × 10−91	1.49 × 10−13	<1.0 × 10−300	1.15 × 10–256	1.76 × 10−119
CVD mortality	1.56*	1.46*	1.23*	1.80*	1.61*	1.32*
	[1.51, 1.61]	[1.42, 1.51]	[1.19, 1.27]	[1.73, 1.87]	[1.55, 1.68]	[1.26, 1.38]
	5.19 × 10−176	2.38 × 10−127	3.38 × 10−34	1.09 × 10−199	2.17 × 10−121	1.74 × 10−37

Results are HRs associated with 1 SD increase in obesity [BMI (log) or WHR], 95% CIs, and P-values from Cox models relating the exposures to incident disease/events in the full sample. One SD BMI (log) = 4.4 kg/m² and 1 SD WHR = 0.09.

*Represent significant associations.