TABLE 1.

GSEA using the Hallmark gene sets comparing the paired brain metastases and primary breast tumors. Gene sets with FDR < 0.05

NAME	SIZE	ES	NES	p-val	FDR q-value
Upregulated gene sets
HALLMARK_PROTEIN_SECRETION	94	0.43057767	2.1916907	0	4.00E-04
HALLMARK_OXIDATIVE_PHOSPHORYLATION	199	0.31743	1.8286253	0	0.007600902
HALLMARK_MTORC1_SIGNALING	199	0.30052698	1.7314858	0	0.01158934
HALLMARK_ANDROGEN_RESPONSE	98	0.33145055	1.716175	8.02E-04	0.009625576
HALLMARK_MITOTIC_SPINDLE	199	0.2636196	1.5251341	0.001647446	0.03683615
Downregulated gene sets
HALLMARK_ALLOGRAFT_REJECTION	167	−0.4972723	−2.4051008	0	0
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	194	−0.4094371	−2.0216177	0	3.57E-04
HALLMARK_KRAS_SIGNALING_UP	178	−0.3900975	−1.9043354	0	0.001021529
HALLMARK_IL2_STAT5_ SIGNALING	187	−0.38098702	−1.8678038	0	0.001213369
HALLMARK_HEDGEHOG_SIGNALING	33	−0.472654	−1.70284	0.006790403	0.007752952
HALLMARK_COAGULATION	103	−0.37336287	−1.6854488	7.97E-04	0.00773936
HALLMARK_APICAL_JUNCTION	184	−0.34352946	−1.6789134	4.89E-04	0.00701823
HALLMARK_INFLAMMATORY_RESPONSE	170	−0.33855027	−1.641233	3.69E-04	0.009221255
HALLMARK_COMPLEMENT	174	−0.31858927	−1.5492525	0.002094628	0.022641048