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. 2023 Apr 6;16(3):236–247. doi: 10.1161/CIRCGEN.122.003710

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© 2023 The Authors.

Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Visualization of 8 selected significant results from interaction analyzes. The bars show odds ratio point estimates for the risk of having carotid intima-media thickness (C-IMT) above the 75th percentile associated with (a) the genetic risk variant without the presence of smoking, (b) smoking without the presence of the genetic risk variant, and (c) the genetic risk variant in combination with smoking. Reference category is nonsmoking without the presence of the genetic risk variant. These 8 SNPs are located in coding genes previously linked to the development of atherosclerosis.