Table 2.
Thromboembolic events in patients hospitalized for COVID-19 (exposed) and matched subjects without COVID-19 (nonexposed) groups.
| Age (y) | COVID-19 status | Early (0 to <60 d) |
Late (60 to <180 d) |
Long term (from 180 d) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Na | During initial hospitalization | After hospitalizationb | Total | Nc | Events | Event rate (per 1000 y) | HR (CI) Model 1d |
HR (CI) Model 2e |
Nc | Events | Event rate (per 1000 y) | HR (CI) Model 1d |
HR (CI) Model 2e |
||
| VTE | |||||||||||||||
| 18-54 | Exposed | 16,242 | 520 | 111 | 631 | 15,396 | 38 | 7.8 | 6.86 (4.21-11.17) | 6.58 (3.95-10.98) | 13,935 | 20 | 2.93 | 2.72 (1.57-4.72) | 2.63 (1.55-4.45) |
| Nonexposed | 81,620 | 14 | 14 | 79,952 | 28 | 1.12 | 69,867 | 35 | 1.09 | ||||||
| 55-64 | Exposed | 10,953 | 523 | 80 | 603 | 9879 | 73 | 23.08 | 10.65 (7.17-15.83) | 10.62 (7.05-16.00) | 9279 | 26 | 5.66 | 2.22 (1.40-3.52) | 2.24 (1.40-3.59) |
| Nonexposed | 55,000 | 20 | 20 | 54,023 | 37 | 2.15 | 50,072 | 62 | 2.63 | ||||||
| 65-74 | Exposed | 10,381 | 531 | 100 | 631 | 8350 | 58 | 21.81 | 4.80 (3.38-6.81) | 4.08 (2.83-5.89) | 7856 | 25 | 6.58 | 1.53 (0.98-2.36) | 1.27 (0.80-2.02) |
| Nonexposed | 52,407 | 45 | 45 | 51,813 | 73 | 4.38 | 49,285 | 105 | 4.41 | ||||||
| 75-84 | Exposed | 10,832 | 406 | 109 | 515 | 7336 | 51 | 21.98 | 3.18 (2.29-4.42) | 2.95 (2.09-4.17) | 6842 | 34 | 9.91 | 1.65 (1.14-2.38) | 1.51 (1.03-2.20) |
| Nonexposed | 54,636 | 63 | 63 | 53,896 | 117 | 6.75 | 51,601 | 160 | 6.02 | ||||||
| Total | Exposed | 48,408 | 1,980 | 400 | 2,380 | 40,961 | 220 | 16.91 | 5.37 (4.48-6.43) | 5.05 (4.19-6.1) | 37,912 | 105 | 5.63 | 1.85 (1.49-2.30) | 1.73 (1.39-2.16) |
| Nonexposed | 243,663 | 142 | 142 | 239,684 | 255 | 3.35 | 220,825 | 362 | 3.41 | ||||||
| PE | |||||||||||||||
| 18-54 | Exposed | 16,264 | 477 | 74 | 551 | 15,497 | 19 | 3.87 | 9.51 (4.43-20.41) | 8.11 (3.53-18.64) | 14,045 | 10 | 1.45 | 3.37 (1.50-7.59) | 2.85 (1.28-6.36) |
| Nonexposed | 81,665 | 5 | 5 | 80,005 | 10 | 0.4 | 69,930 | 14 | 0.43 | ||||||
| 55-64 | Exposed | 10,976 | 482 | 65 | 547 | 9953 | 63 | 19.77 | 18.70 (11.07-31.58) | 19.18 (11.21-32.84) | 9358 | 20 | 4.31 | 2.95 (1.71-5.11) | 3.09 (1.75-5.45) |
| Nonexposed | 55,058 | 7 | 7 | 54,092 | 18 | 1.04 | 50,150 | 36 | 1.52 | ||||||
| 65-74 | Exposed | 10,423 | 500 | 87 | 587 | 8420 | 46 | 17.14 | 5.44 (3.61-8.18) | 4.64 (3.02-7.15) | 7932 | 16 | 4.17 | 1.63 (0.94-2.83) | 1.36 (0.75-2.47) |
| Nonexposed | 52,486 | 27 | 27 | 51,904 | 50 | 3 | 49,384 | 62 | 2.6 | ||||||
| 75-84 | Exposed | 10,881 | 369 | 92 | 461 | 7413 | 37 | 15.77 | 3.37 (2.27-5.00) | 3.08 (2.02-4.68) | 6919 | 22 | 6.34 | 1.93 (1.22-3.08) | 1.74 (1.07-2.83) |
| Nonexposed | 54,736 | 33 | 33 | 54,025 | 79 | 4.54 | 51,748 | 88 | 3.3 | ||||||
| Total | Exposed | 48,544 | 1,828 | 318 | 2,146 | 41,283 | 165 | 12.57 | 6.5 (5.22-8.09) | 6.05 (4.80-7.62) | 38,254 | 68 | 3.61 | 2.18 (1.66-2.87) | 2.01 (1.51-2.68) |
| Nonexposed | 243,945 | 72 | 72 | 240,026 | 157 | 2.06 | 221,212 | 200 | 1.88 | ||||||
| DVT | |||||||||||||||
| 18-54 | Exposed | 16,312 | 58 | 45 | 103 | 15,966 | 25 | 4.95 | 6.39 (3.52-11.61) | 6.70 (3.63-12.38) | 14,452 | 11 | 1.56 | 2.41 (1.16-4.99) | 2.56 (1.29-5.08) |
| Nonexposed | 81,645 | 10 | 10 | 79,980 | 19 | 0.76 | 69,896 | 21 | 0.65 | ||||||
| 55-64 | Exposed | 10,998 | 58 | 26 | 84 | 10,393 | 21 | 6.29 | 4.97 (2.73-9.03) | 4.58 (2.47-8.48) | 9810 | 8 | 1.65 | 1.31 (0.60-2.87) | 1.21 (0.55-2.70) |
| Nonexposed | 55,050 | 14 | 14 | 54,075 | 22 | 1.28 | 50,127 | 30 | 1.27 | ||||||
| 65-74 | Exposed | 10,468 | 52 | 23 | 75 | 8855 | 14 | 4.95 | 3.06 (1.61-5.81) | 2.62 (1.35-5.09) | 8,361 | 11 | 2.73 | 1.35 (0.70-2.59) | 1.13 (0.58-2.21) |
| Nonexposed | 52,483 | 19 | 19 | 51,911 | 27 | 1.62 | 49,412 | 50 | 2.09 | ||||||
| 75-84 | Exposed | 10,925 | 46 | 24 | 70 | 7706 | 17 | 6.96 | 2.71 (1.55-4.75) | 2.70 (1.54-4.74) | 7206 | 16 | 4.44 | 1.44 (0.84-2.45) | 1.41 (0.82-2.43) |
| Nonexposed | 54,751 | 34 | 34 | 54,022 | 44 | 2.53 | 51,765 | 82 | 3.07 | ||||||
| Total | Exposed | 48,703 | 214 | 118 | 332 | 42,920 | 77 | 5.64 | 4.08 (3.06-5.44) | 3.97 (2.96-5.33) | 39,829 | 46 | 2.36 | 1.50 (1.08-2.07) | 1.46 (1.05-2.01) |
| Nonexposed | 243,929 | 77 | 77 | 239,988 | 112 | 1.47 | 221,200 | 183 | 1.72 | ||||||
DVT, deep venous thrombosis; HR, hazard ratio; PE, pulmonary embolism; VTE, venous thromboembolism.
a
Excluding patients with an event occurring between January 1, 2020, and the diagnosis of COVID-19.
b
Refers to events occurring after discharge from first hospitalization. The nonexposed groups include all events occurring during the full 60-day period.
c
Numbers that were alive, had not experienced an event, and were still in follow-up.
d
Model 1 adjusted for age and sex.
e
Model 2 adjusted for age, sex, obesity, hypertension, need for assisted living, born in Nordic country, education, and Charlson Comorbidity Index.