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. 2023 Jun 21;9(25):eadg7865. doi: 10.1126/sciadv.adg7865

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Fig. 8. — Top: Validated de novo compounds targeting (A) M^pro and (B) spike RBD. Bottom: Most similar molecules from PubChem. Values in parenthesis indicate Tanimoto similarity between the machine-designed and nearest PubChem molecules.