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. 2023 Jun 7;11:1045759. doi: 10.3389/fcell.2023.1045759

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Copyright © 2023 Zhao, Veeranan-Karmegam, Baker, Mysona, Bagchi, Liu, Smith, Gonsalvez and Bollinger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global secretome analysis upon ligand treatment. (A) A volcano plot comparing the secretome between control cells versus cells treated with 25uM Haloperidol for 24 h. A line demarcating 2-fold enrichment (+1 and −1 on the x-axis) and a p-value of 0.05 is shown (1.3 on the y-axis). A list of proteins whose secretion is affected greater than two fold is shown below the volcano plot. (B) A volcano plot comparing the secretome between control cells versus cells treated with 20uM (+)-PTZ for 24 h. The layout is similar to panel (A). The proteins in blue were shown to be affected in their secretion under both treatment conditions. (C) A pie chart showing the total number of secreted proteins, the number of proteins found to be biotinylated by S1R-Apex, and the overlap between the two categories.