Table 1.

Summary of chemical conditioning methods used in vivo with viral vector mediated airway gene transfer.

Compound	Concentration	Species	Route of vector delivery	Viral vector type	References
LPC	0.1–2%	Mouse, rat	Nasal	LV, HD-AdV	[43–49, 57, 62, 106]
	0.01–1%	Mouse, rat, ferret, rabbit, sheep, pig, marmoset, baboon	Lung	LV, HD-AdV, piggyBac/AdV	[34, 50–56, 58–64]
PDOC	0.1–1%	Mouse	Nasal	AdV, LV	[45, 66]
C10	30–50 mM	Mouse	Lung	AdV	[38, 74]
EGTA	3–400 mM	Mouse, rabbit	Lung	AdV, HD-AdV, AAV, LV, retroviral	[38, 74, 75, 78–80]
PFC	100%	Mouse, rat, macaque	Lung	AdV, AAV	[84, 86–89, 107]
SO2	500 ppm	Mouse	Nasal and lung	LV, retroviral	[90, 91]

mM millimolar, ppm parts per million.