Table 1.

Identified targets involved in ferroptosis related to anthracycline-induced cardiotoxicity (AIC).

Targets	Mechanism	Effect	Ref.
Genes
Elabela	Upregulating KLF15/GPX4	Inhibiting ferroptosis and protecting cardiomyocytes	[23]
FUNDC2	Downregulating SLC25A11	Inducing ferroptosis and damaging cardiomyocytes	[24]
MITOL	Upregulating GPX4	Inhibiting ferroptosis and protecting cardiomyocytes	[25]
Acot1	Unclear	Inhibiting ferroptosis and protecting cardiomyocytes	[26]
PRMT4	Downregulating Nrf2/GPX4	Inducing ferroptosis and damaging cardiomyocytes	[27]
TRIM21	Unclear	Inducing ferroptosis and damaging cardiomyocytes	[28]
METTL14	Upregulating KCNQ1OT1/miR-7-5p	Inducing ferroptosis and damaging cardiomyocytes	[29]
FoxO4	Upregulating ENPP2	Inhibiting ferroptosis and protecting cardiomyocytes	[30]
Trx1	Upregulating mTORC1	Inhibiting ferroptosis and protecting cardiomyocytes	[31]
SPATA2	Upregulating CYLD	Inducing ferroptosis and damaging cardiomyocytes	[32]
HMOX1	Upregulating CTGF	Inducing ferroptosis and damaging cardiomyocytes	[33]
Compounds
Epigallocatechin-3-gallate	Upregulating GPX4	Inhibiting ferroptosis and protecting cardiomyocytes	[34]
Salidroside	Upregulating GPX4	Inhibiting ferroptosis and protecting cardiomyocytes	[35]
Astragaloside IV	Upregulating Nrf2/GPX4	Inhibiting ferroptosis and protecting cardiomyocytes	[36]
Fisetin	Upregulating SIRT1/Nrf2/GPX4	Inhibiting ferroptosis and protecting cardiomyocytes	[37]
Resveratrol	Upregulating p62/Nrf2/GPX4	Inhibiting ferroptosis and protecting cardiomyocytes	[38]
Propofol	Upregulating Nrf2/GPX4	Inhibiting ferroptosis and protecting cardiomyocytes	[39]
LCZ696	Upregulating AKT/SIRT3/SOD2	Inhibiting ferroptosis and protecting cardiomyocytes	[40]
Melatonin	Upregulating YAP	Inhibiting ferroptosis and protecting cardiomyocytes	[41]
Histamine	Upregulating STAT3/SLC7A11	Inhibiting ferroptosis and protecting cardiomyocytes	[42]