Table 1.
Clinical, biochemical, and instrumental parameters of subjects with JIA and healthy controls
| Parameters | JIA (N = 49) |
Controls (n = 49) |
p-value | Adjusted p for sex |
|---|---|---|---|---|
| Anthropometric parameters | ||||
| Sex (male/female) | 9/40 | 24/25 | 0.001 | |
| Age (years) | 10.3 ± 3.8 | 11.3 ± 3.4 | 0.19 | |
| Age at onset (years) | 4.8 ± 3.1 | – | ||
| Age at start of therapy (years) | 6.8 ± 3.5 | – | ||
| Duration of disease (years) | 5.5 ± 3.3 | – | ||
| JADAS 27 | 1.4 ± 1.3 | – | ||
| Active/inactive disease | 19/30 | – | ||
| Weight (kg) | 36.8 ± 15.9 | 42.9 ± 17.3 | 0.07 | |
| Weight SDS | − 0.16 ± 1.20 | − 0.06 ± 1.07 | 0.67 | |
| Height (cm) | 139.2 ± 22.1 | 144.5 ± 20.6 | 0.22 | |
| Height SDS | − 0.02 ± 1.24 | − 0.22 ± 1.27 | 0.43 | |
| BMI (kg/m2) | 18.1 ± 3.4 | 19.6 ± 3.7 | 0.03 | |
| BMI SDS | − 0.55 ± 2.54 | 0.17 ± 1.06 | 0.07 | |
| Laboratory parameters | ||||
| Creatinine (mg/dl) | 0.5 ± 0.1 | 0.6 ± 0.1 | < 0.001 | 0.001 |
| eGFR (ml/min/1.73 m2) | 99.2 ± 10.5 | 122.5 ± 19.8 | < 0.001 | < 0.001 |
| Cystatin C (mg/dl) | 0.8 ± 0.1 | 0.7 ± 0.1 | < 0.001 | < 0.001 |
| BUN (mg/dl) | 13.3 ± 2.9 | 11.7 ± 1.4 | 0.001 | 0.001 |
| UAE | 1.1 (1.05–1.10) |
1.0 (1.01–1.06) |
0.003 | 0.01 |
| ESR (mm/h) |
11 (6–19) |
1 (1–1) |
< 0.001 | < 0.001 |
| CRP (mg/dl) |
0.2 (0.2–0.85) |
0.2 (0.2–0.2) |
< 0.001 | < 0.001 |
| US parameters | ||||
| Right RRI | 0.7 ± 0.1 | 0.6 ± 0.04 | < 0.001 | < 0.001 |
| Left RRI | 0.7 ± 0.1 | 0.6 ± 0.04 | < 0.001 | < 0.001 |
| Mean RRI | 0.7 ± 0.04 | 0.6 ± 0.04 | < 0.001 | < 0.001 |
| Right length | 10. 8 ± 10.9 | 8.3 ± 0.8 | 0.11 | 0.14 |
| Left length | 10.9 ± 10.9 | 8.3 ± 0.8 | 0.1 | 0.13 |
| Right width | 1.5 ± 0.3 | 1.8 ± 0.4 | < 0.001 | 0.004 |
| Left width | 1.5 ± 0.3 | 1.8 ± 0.4 | < 0.001 | 0.002 |
Data are mean ± SD or median (IQR)
SDS—standard deviation score; e-GFR—estimated glomerular filtration rate; UAE—urinary albumin excretion; RRI—renal resistive index; BUN—blood urea nitrogen; ESR—erythrocyte sedimentation rate; CRP—C-reactive protein